HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 22494085, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 4-(Trifluoromethyl)phenol | HCID 67874 | — |
| Reactant | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| Reactant | 4-Ethoxy-2-methoxyphenol | HCID 54107015 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22494085 | HCID 22494085 | 90.8% |
Reaction Steps
1.1 g of 4-hydroxybenzotrifluoride and 1.0 g of 2-methoxyphenetyl alcohol were dissolved in 200 ml tetrahydrofuran. 2.6 g of triphenyl phosphine and 2.0 g of diisopropyl azodicarboxylate were added thereto, followed by stirring at room temperature for 24 hours. After evaporating the solvent, the residue was subjected to silica gel column chromatography, to give 1.6 g of 1-methoxy-2-{2-[4-(trifluoromethyl)phenoxy]ethyl}benzene was obtained from fractions eluted with hexane-ethyl acetate (10:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06884821B1 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-46dd770fbde447c4a782279415b7576f |
| Source note | uspto-grants-2005_04 |