HCID 73989463, compound → HCID 22494254, compound

Participants

Reaction Steps

0.55 g of N1-(5-[(2,4-dioxo-1,3-thiazolane-5-ylidene)methyl]-2-methoxybenzyl)-4-(trifluoromethyl)benzamide was suspended in 20 ml N,N-dimethylformamide, and 0.60 g of 10% palladium-carbon was added, and the mixture was stirred at 50° C. under pressure at 15 kg/cm2 hydrogen for 16 hours. After the reaction, the catalyst was filtered off, and after the solvent was evapoarated. Water was added to the residue, followed by extracting with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evapoarated. The residue was subjected to silica gel column chromatography, and from fractions eluted with hexane-ethyl acetate (1:1), 1.2 g of N1-{5-[(2,4-dioxo-1,3-thiazolane-5-yl)methyl]-2-methoxybenzyl}-4-(trifluoromethyl)benzamide was obtained.

Provenance & Evidence