反应详情

6.04 g of tertiary butyl N-(2-methoxybenzyl)carbamate was dissolved in 50 ml acetonitrile, followed by adding 4.6 g of N-bromosuccinimide thereto. After stirring at room temperature for 3 hours, the solvent was evaporated. The residue was dissolved in ethyl acetate and successively-washed with water and brine. The organic layer was dried over anhydrous magnesium sulfate and the solvent was evapoarated. The residue was washed with a mixture of methyl tertiary butyl methyl ether and hexane, to give 6.97 g of tertiary butyl N-(5-bromo-2-methoxybenzyl)carbamate.

1. customthe solvent was evaporated
2. dissolutionThe residue was dissolved in ethyl acetate
3. washsuccessively-washed with water and brine
4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
5. washThe residue was washed with a mixture of methyl tertiary butyl methyl ether and hexane