(2-Chloro-4-methoxyphenyl)methanol → 3-(3-[(2-Chloro-4-methoxybenzyl)oxy]methyl-4-methoxyphenyl)-2-isopropoxy propanoic acid

HRID 1816634Notes

Reaction equation

HRID 1816634 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH2:10][OH:11].Br[CH2:13][C:14]1[CH:15]=[C:16]([CH2:22][CH:23]([O:27][CH:28]([CH3:30])[CH3:29])[C:24]([O-:26])=[O:25])[CH:17]=[CH:18][C:19]=1[O:20][CH3:21]>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH2:10][O:11][CH2:13][C:14]1[CH:15]=[C:16]([CH2:22][CH:23]([O:27][CH:28]([CH3:30])[CH3:29])[C:24]([OH:26])=[O:25])[CH:17]=[CH:18][C:19]=1[O:20][CH3:21]

Participants

3

Reactant 2

HCID 14771756(2-Chloro-4-methoxyphenyl)methanolHCID 224938933-[3-(Bromomethyl)-4-methoxyphenyl]-2-isopropoxypropanoate

Product 1

HCID 207773383-(3-[(2-Chloro-4-methoxybenzyl)oxy]methyl-4-methoxyphenyl)-2-isopropoxy propanoic acid

Procedure

Using (2-chloro-4-methoxyphenyl)methanol and 3-[3-(bromomethyl)-4-methoxyphenyl]-2-isopropoxypropanoate, 3-(3-[(2-chloro-4-methoxybenzyl)oxy]methyl-4-methoxyphenyl)-2-isopropoxy propanoic acid was obtained in the same method as in Example 247).

Sources & evidence

ORD record
ord-8885e695ed754d6480e7d42518ecaefc
Source dataset
uspto-grants-2005_04
Patent number
US06884821B1

Reaction notes

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