(4-Phenoxyphenyl)methanol → 2-Isopropoxy-3-(4-methoxy-3-[(4-phenoxybenzyl)oxy]methylphenyl)propanoic acid
Reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][OH:15])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:17][C:18]1[CH:19]=[C:20]([CH2:26][CH:27]([O:31][CH:32]([CH3:34])[CH3:33])[C:28]([O-:30])=[O:29])[CH:21]=[CH:22][C:23]=1[O:24][CH3:25]>>[CH:32]([O:31][CH:27]([CH2:26][C:20]1[CH:21]=[CH:22][C:23]([O:24][CH3:25])=[C:18]([CH2:17][O:15][CH2:14][C:11]2[CH:10]=[CH:9][C:8]([O:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:13][CH:12]=2)[CH:19]=1)[C:28]([OH:30])=[O:29])([CH3:33])[CH3:34]Participants
3
Procedure
Using (4-phenoxyphenyl)methanol and 3-[3-(bromomethyl)-4-methoxyphenyl]-2-isopropoxypropanoate, 2-isopropoxy-3-(4-methoxy-3-[(4-phenoxybenzyl)oxy]methylphenyl)propanoic acid was obtained in the same method as in Example 247).
Sources & evidence
- ORD record
- ord-7bfd437c8dc94a0aa5a972fbd19d1444
- Source dataset
- uspto-grants-2005_04
- Patent number
- US06884821B1
Reaction notes
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