Thiazolidinedione → 5-[4-Methoxy-3-([4-(trifluoromethyl)benzyl]oxymethyl)benzyl]-1,3-thiazolane-2,4-dione

HRID 1816641Notes

Reaction equation

HRID 1816641 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][C:4]=1[CH2:11][O:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=1.[S:24]1[CH2:28][C:27](=[O:29])[NH:26][C:25]1=[O:30]>>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][CH:28]2[S:24][C:25](=[O:30])[NH:26][C:27]2=[O:29])=[CH:5][C:4]=1[CH2:11][O:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 5437ThiazolidinedioneHCID 224942944-Methoxy-3-({[4-(trifluoromethyl)benzyl]oxy}methyl)benzaldehyde

Product 1

HCID 224942075-[4-Methoxy-3-([4-(trifluoromethyl)benzyl]oxymethyl)benzyl]-1,3-thiazolane-2,4-dione

Procedure

Using 4-methoxy-3-({[-4-(trifluoromethyl)benzyl]oxy}methyl)benzaldehyde and 2,4-thiazolidinedione, 5-[4-methoxy-3-([4-(trifluoromethyl)benzyl]oxymethyl)benzyl]-1,3-thiazolane-2,4-dione was obtained in the same method as in Production Example 27c) and then in Example 29).

Sources & evidence

ORD record
ord-d9c1e9ce69df4868b76286e2b8565328
Source dataset
uspto-grants-2005_04
Patent number
US06884821B1

Reaction notes

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