3-(3-([(Tert-butoxycarbonyl)amino]methyl)-4-methoxyphenyl]-2-isopropoxypropanoate → 3-(3-[(2-Ethoxy-4-(trifluoromethyl)benzoyl]aminomethyl)-4-methoxyphenyl]-2-isopropoxypropanoic acid

HRID 1816662Notes

Reaction equation

HRID 1816662 reaction equation
[CH2:1]([O:3][C:4]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=O)[CH3:2].C(OC([NH:24][CH2:25][C:26]1[CH:27]=[C:28]([CH2:34][CH:35]([O:39][CH:40]([CH3:42])[CH3:41])[C:36]([O-:38])=[O:37])[CH:29]=[CH:30][C:31]=1[O:32][CH3:33])=O)(C)(C)C>>[CH2:1]([O:3][C:4]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[CH:9][C:5]=1[C:6]([NH:24][CH2:25][C:26]1[CH:27]=[C:28]([CH2:34][CH:35]([O:39][CH:40]([CH3:42])[CH3:41])[C:36]([OH:38])=[O:37])[CH:29]=[CH:30][C:31]=1[O:32][CH3:33])=[O:8])[CH3:2]

Participants

3

Reactant 2

HCID 224939543-(3-([(Tert-butoxycarbonyl)amino]methyl)-4-methoxyphenyl]-2-isopropoxypropanoateHCID 224943272-Ethoxy-4-(trifluoromethyl)benzoic acid

Product 1

HCID 224941893-(3-[(2-Ethoxy-4-(trifluoromethyl)benzoyl]aminomethyl)-4-methoxyphenyl]-2-isopropoxypropanoic acid

Procedure

Using 2-ethoxy-4-(trifluoromethyl)benzoic acid and 3-[3-([(tert-butoxycarbonyl)amino]methyl)-4-methoxyphenyl]-2-isopropoxypropanoate, 3-(3-[(2-ethoxy-4-(trifluoromethyl)benzoyl]aminomethyl)-4-methoxyphenyl]-2-isopropoxypropanoic acid was obtained in the same method as in Example 38).

Sources & evidence

ORD record
ord-203f0564c11f4fb598f1f23ec385dfc2
Source dataset
uspto-grants-2005_04
Patent number
US06884821B1

Reaction notes

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