反应详情

4-Chloro-2-hydroxymethyl-3-methoxypyridine (41.0 g) was dissolved in methylene chloride (150 mL), and thionyl chloride was added dropwise over 10 minutes with stirring under cooling with an ice bath. The ice bath was removed, and the mixture was stirred for 30 minutes at room temperature. The solvent was removed under reduced pressure, and hexane (50 mL) was added to the residue, followed by distillation, whereby 4-chloro-2-chloromethyl-3-methoxypyridine chloride was obtained as a brown solid (54.1 g, yield: quantitative).

1. temperatureunder cooling with an ice bath
2. customThe ice bath was removed
3. stirringthe mixture was stirred for 30 minutes at room temperature
4. customThe solvent was removed under reduced pressure, and hexane (50 mL)
5. additionwas added to the residue
6. distillationfollowed by distillation