2,2,2-Trifluoroethanol → 2-(2,2,2-Trifluoroethoxy)ethan-1-ol

Participants

Reaction Conditions

Reaction Steps

2,2,2-Trifluoroethanol (24.0 g), triethylamine (24.0 g), tetrabutylammonium iodide (1.7 g), and ethylene carbonate (30.5 g) were mixed, and the mixture was heated at 100° C. (internal temperature) and stirred for 36 hours. The reaction mixture was concentrated under reduced pressure at room temperature, and then subjected by distillation (67° C., 30 mmHg), whereby 2-(2,2,2-trifluoroethoxy)ethanol was obtained (24.7 g, yield: 71%).

Provenance & Evidence