Methylparaben → HCID 22494693, compound

Participants

Reaction Steps

To a mixture of methyl 4-hydroxybenzoate (1.52 g) and potassium carbonate (0.76 g) in acetone (30 ml) was added dropwise a solution of 1,7-dibromoheptane (3.1 g) in acetone (10 ml) at room temperature with stirring. The mixture was stirred at room temperature for 2.5 hours, and then refluxed for overnight with stirring. The reaction mixture was filtered under reduced pressure and the filtrate was concentrated under reduced pressure to give an oily solid. The oily solid was subjected to column chromatography on silica gel (silica gel 60 F254, Merck: 200 g) and eluted with a mixture of ethyl acetate and n-hexane (1:3). The fractions containing the objective compound were combined and concentrated under reduced pressure to give methyl 4-(7-bromo-n-heptyloxy]benzoate (2.3 g).

Provenance & Evidence