HCID 22492926, compound → HCID 22492895, compound

Participants

Reaction Steps

To a solution of 4-(5-bromopentyloxy)-1-N-t-butyloxycarbonylpiperidine (2.44 g) in methanol (13 ml) was added 28% sodium methoxide methanol solution (14.2 ml), and the mixture was stirred under reflux for 4 hours. The reaction mixture was evaporated in vacuo. The resulting residue was chromatographed on silica gel (250 ml) eluting with a mixture of n-hexane and ethyl acetate (5:1 v/v). The fractions containing the object compound were collected and evaporated under reduced pressure to give 4-(5-methoxypentyloxy)-1-N-t-butyloxycarbonylpiperidine (1.97 g).

Provenance & Evidence