Hydrogen chloride-ethyl acetate → HCID 22492917, compound

Participants

Reaction Steps

To a solution of 4-(5-methoxypentyloxy)-1-N-t-butyloxycarbonylpiperidine (1.97 g) in ethyl acetate (20 ml) was added 4N-hydrogen chloride ethyl acetate solution (16.3 ml), and the mixture was stirred at ambient temperature for 2 hours. The reaction mixture was evaporated in vacuo. The resulting residue was dissolved in a mixture of dichloromethane and methanol (10:1; 50 ml:5 ml). To this solution was added 1N-sodium hydroxide (5 ml) with stirring. The organic layer was separated and evaporated under reduced pressure to give 4-(5-methoxypentyloxy)piperidine (0.62 g).

Provenance & Evidence