Water → HCID 22494735, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(4-methanesulfonyloxypiperidin-1-yl)benzonitrile (4.90 g) in N,N-dimethylformamide (DMF) (50 ml) were added potassium carbonate (4.83 g) and 2,6-dimethylmorpholine (3.02 g), and the mixture was stirred at 90-95° C. for 6 hours. After cooling, the reaction mixture was poured into water (300 ml) and extracted twice with a mixture of ethyl acetate and n-hexane (100 ml:30 ml). The extracts were combined and washed in turn with water and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and evaporated in vacuo. The resulting precipitates were washed with IPE (100 ml), collected by filtration and dried in vacuo to give 4-[4-(2,6-dimethylmorpholin-4-yl)piperidin-1-yl]benzonitrile (2.29 g).

Provenance & Evidence