Hydrochloric Acid → HCID 22494632, compound

Participants

Reaction Steps

To a solution of 4-[1-[4-(4-propylthiopiperidin-1-yl)phenyl]piperazin-4-yl]benzoic acid ethyl ester (1.22 g) in a mixture of ethanol (10 ml) and tetrahydrofuran (40 ml) was added 10% aqueous NaOH (2.1 ml) and 1N-NaOR (10 ml), and the mixture was refluxed for 6 hours. The reaction mixture was cooled and adjusted to pH 2.5-3.0 with 1N-HCl. The resulting precipitates were collected by filtration, washed in turn with water (30 ml) and IPE (50 ml) and dried in vacuo to give 4-[1-[4-(4-propylthiopiperidin-1-yl)phenyl]piperazin-4-yl]benzoic acid (0.99 g).

Provenance & Evidence