HCID 22494777, compound → HCID 22494630, compound

Participants

Reaction Steps

To a solution of 4-(6-bromohexylthio)-N-t-butyloxycarbonylpiperidine (4.95 g) in methanol (20 ml) was added 28% sodium methoxide methanol solution (26.6 ml), and the mixture was stirred under reflux for 4 hours. After cooling, the reaction mixture was evaporated in vacuo. The resulting residue was chromatographed on silica gel (400 ml) eluting with a mixture of n-hexane and ethyl acetate (5:1 v/v). The fractions containing the object compound were collected and evaporated under reduced pressure to give 4-(6-methoxyhexylthio)-N-t-butyloxycarbonylpiperidine (3.32 g).

Provenance & Evidence