Hydrochloric Acid → HCID 69677694, compound

Participants

Reaction Steps

A mixture of ethyl 4-[4-[4-(3-cyclohexyloxypropyloxy)phenyl]piperazin-1-yl]benzoate (290 mg) in the mixed solvent of tetrahydrofuran (15 ml) and ethanol (3 ml) was treated with 10% sodium hydroxide aqueous solution (0.50 ml), and the mixture was refluxed for 8 hours. After cooling, water was added to the reaction mixture, and the acidity of the mixture was adjusted to pH 1 with 1N-hydrochloric acid. The resulting precipitate was filtered, washed with water and dried under reduced pressure to give 4-[4-[4-(3-cyclohexyloxypropyloxy)phenyl]piperazin-1-yl]benzoic acid dihydrochloride (96 mg) as a pale brown solid.

Provenance & Evidence