Sodium Hydroxide → HCID 22494741, compound

HRID 1816735Notes

Reaction equation

HRID 1816735 reaction equation
Cl.Cl.Cl.[C:4]1([CH:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([N:22]4[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]4)=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[OH-].[Na+]>ClCCl>[C:4]1([CH:10]2[CH2:11][CH2:12][N:13]([C:16]3[CH:21]=[CH:20][C:19]([N:22]4[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]4)=[CH:18][CH:17]=3)[CH2:14][CH2:15]2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22494746HCID 22494746, compound

Product 1

HCID 22494741HCID 22494741, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 4-[4-(4-phenylpiperidin-1-yl)phenyl]piperazine trihydrochloride salt (1.77 g) and 1N-sodium hydroxide (62 ml) in dichloromethane (62 ml) was stirred for 30 minutes at ambient temperature. The organic layer was separated, washed with brine, dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 1-[4-(4-phenylpiperidin-1-yl)phenyl]piperazine (1.19 g).

Workup

  1. customThe organic layer was separated
  2. washwashed with brine
  3. dry with materialdried over magnesium sulfate
  4. filtrationThe magnesium sulfate was filtered off
  5. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-574c8014e93e4b30b785f0f392cc983c
Source dataset
uspto-grants-2005_04
Patent number
US06884868B1

Reaction notes

Loading…