Sodium Hydroxide → HCID 22494762, compound

HRID 1816742Notes

Reaction equation

HRID 1816742 reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:21][CH2:20][CH:19]([O:22][CH:23]4[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]4)[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>C(O)C>[CH:23]1([O:22][CH:19]2[CH2:20][CH2:21][N:16]([C:13]3[CH:14]=[CH:15][C:10]([N:7]4[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]4)=[CH:11][CH:12]=3)[CH2:17][CH2:18]2)[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22494609HCID 22494609, compound

Product 1

HCID 22494762HCID 22494762, compoundYield 97.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1-acetyl-4-[4-(4-cyclohexyloxypiperidin-1-yl)phenyl]piperazine (0.37 g) and 10% sodium hydroxide (1.9 ml) in ethyl alcohol (7.4 ml) was refluxed for 10 hours. The reaction mixture was evaporated under reduced pressure. The residue was washed with water, and dried to give 1-[4-(4-cyclohexyloxypiperidin-1-yl)phenyl]piperazine (0.32 g).

Workup

  1. temperaturewas refluxed for 10 hours
  2. customThe reaction mixture was evaporated under reduced pressure
  3. washThe residue was washed with water
  4. customdried

Sources & evidence

ORD record
ord-87bd08ba3b74412b8dd45537987c9f06
Source dataset
uspto-grants-2005_04
Patent number
US06884868B1

Reaction notes

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