Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Methyl 4-(chlorocarbonyl)benzoate | HCID 81850 | — |
| Reactant | HCID 69677721 | HCID 69677721 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 53959969 | HCID 53959969 | 87.7% |
Reaction Steps
A mixture of 4-(cis-2,6-dimethylmorpholin-4-yl)benzoic acid hydrazide (458 mg), 4-methoxycarbonylbenzoyl chloride (622 mg) and pyridine (5 ml) in tetrahydrofuran (10 ml) was stirred for 6 hours at 0° C. The reaction mixture was added to water. The resulting precipitates were filtered, washed with water and dried to give 4-[N′-[4-(cis-2,6-dimethylmorpholin-4-yl)benzoyl]hydrazinocarbonyl]benzoic acid methyl ester (662.8 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06884868B1 |
|---|
| Source dataset | uspto-grants-2005_04 |
|---|
| ORD ID | ord-f4f5645fdbb34020a64a9364c5e28749 |
|---|
| Source note | uspto-grants-2005_04 |
|---|
