Hydrochloric Acid → HCID 53913075, compound

Participants

Reaction Steps

A mixture of 4-[5-[4-(cis-2,6-dimethylmorpholin-4-yl)phenyl][1,3,4]thiadiazol-2-yl]benzoic acid methyl ester (527 mg) and 1.0 mol/l sodium hydroxide solution (2.6 ml) in a mixed solvent of methanol (10 ml) and tetrahydrofuran (25 ml) was refluxed for 6 hours. After cooling to ambient temperature, the reaction mixture was poured into cold water and the mixture was adjusted with 1.0 mol/l hydrochloric acid. The resulting precipitates were filtered, washed with water and dried to give 4-[5-[4-(cis-2,6-dimethylmorpholin-4-yl)phenyl][1,3,4]thiadiazol-2-yl]benzoic acid (429.1 mg).

Provenance & Evidence