HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl 4-(piperazin-1-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Ethyl 4-(piperazin-1-yl)benzoate | HCID 2761178 | 66.3% |
Reaction Steps
A solution of piperazine (30.37 g), 4-fluorobenzoic acid ethyl ester (20 g) and potassium carbonate (65.75 g) in dimethylsulfoxide (100 ml) was stirred for 5.5 hours at 150° C. After cooling to the room temperature, water was added to the solution. The resulting precipitate was collected by filtration and dried to give ethyl 4-piperazinylbenzoate (18.48 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06884868B1 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-5974fcde3c71404186897513a5334111 |
| Source note | uspto-grants-2005_04 |