Cesium carbonate → HCID 69677648, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of cesium carbonate (1.43 g), palladium(II) acetate (35 mg) and 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (146 mg) in dioxane (6 ml) was successively added trifluoromethanesulfonic acid 4′-(cis-2,6-dimethylmorpholin-4-yl)-1,1′-biphenyl-4-yl ester (1.30 g) and ethyl 4-piperazinylbenzoate (0.88 g) in a stream of nitrogen. The mixture was stirred at ambient temperature for 30 minutes and at 100° C. for further 6.5 hours. After cooling to room temperature, water was added to the reaction mixture. The resulting precipitates were filtered, washed with water and dried. The residue was pulverized with acetone and collected by filtration to give 4-[4-[4′-(cis-2,6-dimethylmorpholin-4-yl)-1,1′-biphenyl-4-yl]piperazinyl]benzoic acid ethyl ester (1.17 g).

Provenance & Evidence