HCID 21877256, compound → HCID 22494885, compound

HRID 1816789Notes

Reaction equation

HRID 1816789 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12](C2C=C3C(C(C4C=CC5C(=CC=CC=5)C=4)=NN3S(C3C(C)=CC(C)=CC=3C)(=O)=O)=CC=2)=[CH:11][C:10]=1[O:46][CH3:47])C1C=CC=CC=1.C(OC1C=CC([C:62]2[CH:70]=[C:69]3[C:65]([C:66]([C:71]4[CH:80]=[CH:79][C:78]5[C:73](=[CH:74][CH:75]=[CH:76][CH:77]=5)[CH:72]=4)=[N:67][NH:68]3)=[CH:64][CH:63]=2)=CC=1OC)C1C=CC=CC=1>C(OCC)(=O)C.CCCCCC>[CH:72]1[C:73]2[C:78](=[CH:77][CH:76]=[CH:75][CH:74]=2)[CH:79]=[CH:80][C:71]=1[C:66]1[C:65]2[C:69](=[CH:70][CH:62]=[CH:63][CH:64]=2)[N:68]([C:12]2[CH:13]=[CH:14][C:9]([OH:8])=[C:10]([O:46][CH3:47])[CH:11]=2)[N:67]=1

Participants

4

Reactant 2

HCID 21877256HCID 21877256, compoundHCID 21877272HCID 21877272, compound

Product 1

HCID 22494885HCID 22494885, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

6-(4-Benzyloxy-3-methoxy-phenyl)-3-naphthalen-2-yl-1-(2,4,6-trimethyl-benzenesulfonyl)-1H-indazole was converted to 6-(4-benzyloxy-3-methoxy-phenyl)-3-naphthalen-2-yl-1H-indazole as described in Example 1(a), step (ix). Rf sm 0.40, p 0.17 (ethyl acetate-hexane 3:7); 1H NMR (CDCl3) δ 8.40 (s, 1H), 8.12 (d, 1H, J=8.5 Hz), 8.10 (dd, 1H, J=1.6, 8.4 Hz), 7.93 (d, 1H, J=8.3 Hz), 7.88 (m, 2H), 7.61 (m, 1H) 7.56 (s, 1H), 7.43 (m, 5H), 7.30 (m 3H), 7.15 (d, 1H, J=2.0 Hz), 7.08 (dd, 1H, J=2.1, 8.3 Hz), 6.91 (d, 1H, J=8.3 Hz), 5.16 (s, 2H), 3.91 (s, 3H).

Sources & evidence

ORD record
ord-ebf81cfb8e09424caffbc910304bff02
Source dataset
uspto-grants-2005_04
Patent number
US06884890B2

Reaction notes

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