1-(2-Amino-5-bromophenyl)ethan-1-one → 1-(2-Amino-5-bromophenyl)-1-phenylethanol

Participants

Reaction Steps

Prepared from 1-(2-amino-5-bromo-phenyl)-ethanone and phenyl magnesium bromide generally according to the procedure described in example 1. 1H-NMR (DMSO-d6) δ 7.32-7.16 (m, 6H), 7.11 (dd, J=2.03, 8.48 Hz, 1H), 6.49 (d, J=8.55 Hz, 1H), 6.02 (s, 1H), 5.16 (s, 2H), 1.74 (s, 3H); MS (ES) m/z 274/276 ([M+H]+, 100%); Anal. Calc. For C14H14BrNO: C, 57.55; H, 4.83; N, 4.79. Found: C, 57.67; H, 4.83; N, 4.79.

Provenance & Evidence