1-(2-Amino-5-bromophenyl)ethan-1-one → HCID 68867465, compound

HRID 1816892Notes

Reaction equation

HRID 1816892 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].[S:12]1[CH:16]=[CH:15][C:14]([Li])=[CH:13]1>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:14]1[CH:15]=[CH:16][S:12][CH:13]=1)([OH:11])[CH3:10]

Participants

3

Reactant 2

HCID 110747461-(2-Amino-5-bromophenyl)ethan-1-oneHCID 178506756HCID 178506756, compound

Product 1

HCID 68867465HCID 68867465, compound

Procedure

Prepared from 1-(2-amino-5-bromo-phenyl)-ethanone and 3-thienyllithium generally according to the procedure described in example 1. 1H-NMR (DMSO-d6) δ 7.43 (dd, J=2.98, 4.98 Hz, 1H), 7.33 (dd, J=1.27, 2.94 Hz, 1H), 7.07 (dd, J=2.37, 8.47 Hz, 1H), 7.04 (d, J=2.33 Hz, 1H), 6.92 (dd, J=1.26, 4.98 Hz, 1H), 6.52 (d, J=8.38 Hz, 1H), 5.99 (bs, 1H), 5.32 (bs, 2H), 1.78 (s, 3H).

Sources & evidence

ORD record
ord-6dd116f3b2624f218bbe24b24fbbcfe4
Source dataset
uspto-grants-2009_10
Patent number
US07598237B2

Reaction notes

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