Chloroacetyl chloride → HCID 68864153, compound

HRID 1816893Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:12]1[CH:16]=[CH:15][S:14][CH:13]=1)([OH:11])[CH3:10].[Cl:17][CH2:18][C:19](Cl)=[O:20]>>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:19](=[O:20])[CH2:18][Cl:17])=[C:3]([C:9]([OH:11])([C:12]2[CH:16]=[CH:15][S:14][CH:13]=2)[CH3:10])[CH:4]=1

Participants

Reactant 2

HCID 6577Chloroacetyl chloride

HCID 68867465HCID 68867465, compound

Product 1

HCID 68864153HCID 68864153, compound

Procedure

Prepared from 1-(2-amino-5-bromophenyl)-1-thien-3-ylethanol and chloroacetyl chloride generally according to the procedure described in example 1. 1H-NMR (DMSO-d6) δ 10.80 (s, 1H), 8.03 (d, J=7.5 Hz, 1H), 7.52-7.43 (m, 2H), 7.40 (m, 2H), 7.00 (s, 1H), 6.93 (m, 1H), 4.30 (d, J=15.00 Hz, 1H), 4.23 (d, J=15.00 Hz, 1H), 1.90 (s, 3H); MS (ES) m/z 372/374/376 ([M−H]−, 100%).

Sources & evidence

ORD record: ord-d8d33ae440ec4b6098c97b37851fee7a
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07598237B2

Reaction notes

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