Methyl 2-amino-5-bromobenzoate → HCID 68866291, compound

HRID 1816895Notes

Reaction equation

HRID 1816895 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][C:3]=1[C:4]([O:6]C)=O.[S:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[Li]>>[NH2:1][C:2]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][C:3]=1[C:4]([C:14]1[S:13][CH:17]=[CH:16][CH:15]=1)([C:14]1[S:13][CH:17]=[CH:16][CH:15]=1)[OH:6]

Participants

3

Reactant 2

HCID 736224Methyl 2-amino-5-bromobenzoateHCID 178418439HCID 178418439, compound

Product 1

HCID 68866291HCID 68866291, compound

Procedure

Prepared from methyl 2-amino-5-bromobenzoate and 2-thienyllithium using the procedure similar to example 6. 1H-NMR (CDCl3) δ 7.35 (dd, J=5.3, 1.1 Hz, 2H), 7.26 (dd, J=8.4, 2.3 Hz, 1H), 6.98 (m, 2H), 6.82 (d, J=2.3 Hz, 1H), 6.79 (m, 2H), 6.62 (d, J=8.4 Hz, 1H), 5.45 (br s, 1H), 3.86 (br s, 2H); Anal. Calc. For C15H12BrNOS2: C, 49.18, H, 3.30; N, 3.82. Found: C, 49.62, H, 3.47; N, 3.60.

Sources & evidence

ORD record
ord-1df92e4082ec46008979c49fbec67e32
Source dataset
uspto-grants-2009_10
Patent number
US07598237B2

Reaction notes

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