(3-Chlorophenyl)boronic acid → HCID 11371698, compound

HRID 1816905Notes

Reaction equation

HRID 1816905 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][O:8][CH:7]([C:13]3[S:14][CH:15]=[CH:16][CH:17]=3)[C:6]=2[CH:18]=1.[Cl:19][C:20]1[CH:21]=[C:22](B(O)O)[CH:23]=[CH:24][CH:25]=1>>[Cl:19][C:20]1[CH:25]=[C:24]([C:2]2[CH:3]=[CH:4][C:5]3[NH:11][C:10](=[O:12])[CH2:9][O:8][CH:7]([C:13]4[S:14][CH:15]=[CH:16][CH:17]=4)[C:6]=3[CH:18]=2)[CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 2734323(3-Chlorophenyl)boronic acidHCID 68864098HCID 68864098, compound

Product 1

HCID 11371698HCID 11371698, compound

Procedure

Prepared from 7-bromo-5-thien-2-yl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one and 3-chlorobenzeneboronic acid generally according to the procedure described in example 1. 1H-NMR (CDCl3) δ 8.26 (br s, 1H), 7.51 (dd, J=8.3, 2.1 Hz, 1H), 7.45 (d, J=0.9 Hz, 1H), 7.42 (dd, J=5.1, 0.9 Hz, 1H), 7.36 (m, 3H), 7.24 (d, J=2.0 Hz, 1H), 7.05 (m, 2H), 6.93 (d, J=3.5 Hz, 1H), 6.24 (s, 1H), 4.56 (d, J=17.0 Hz, 1H), 4.47 (d, J=17.0 Hz, 1H); MS (ES) m/z 356 (M+H)+; Anal. Calc. For C19H14ClNO2S: C, 64.13, H, 3.97; N, 3.94. Found: C, 64.1, H, 3.83; N, 3.99.

Sources & evidence

ORD record
ord-759c1039c1a24f76ba3b49bfb3beb340
Source dataset
uspto-grants-2009_10
Patent number
US07598237B2

Reaction notes

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