1-(2-Amino-5-bromophenyl)ethan-1-one → HCID 68865081, compound

HRID 1816906Notes

Reaction equation

HRID 1816906 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([Br:10])[CH:7]=[CH:6][C:5]=1[NH2:11])=[O:3].[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Li]>>[NH2:11][C:5]1[CH:6]=[CH:7][C:8]([Br:10])=[CH:9][C:4]=1[C:2]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][N:12]=1)([OH:3])[CH3:1]

Participants

3

Reactant 2

HCID 110747461-(2-Amino-5-bromophenyl)ethan-1-oneHCID 178506720HCID 178506720, compound

Product 1

HCID 68865081HCID 68865081, compound

Procedure

Prepared from 2-amino-5-bromophenyl methyl ketone and 2-pyridyllithium generally according to the procedure described in example 1. 1H NMR (DMSO-d6): δ 8.5 (d, J=3.99 Hz, 1H), 7.77 (dt, J=7.77, 1.79 Hz, 1H), 7.64 (d, J=7.96 Hz, 1H), 7.30 (d, J=2.37 Hz, 1H), 7.21-7.25 (m, 1H), 7.06 (dd, J=8.49, 2.36 Hz, 1H), 6.47 (d, J=8.51 Hz, 1H), 6.18 (s, 1H), 5.26 (s, 2H), 1.8 (s, 3H); MS (ESI) m/z 293/295, 1 Br pattern ([M+H]+).

Sources & evidence

ORD record
ord-244e89b002de49da88c323eb152c2554
Source dataset
uspto-grants-2009_10
Patent number
US07598237B2

Reaction notes

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