Lawesson's reagent → HCID 11223971, compound

Participants

Reaction Steps

Prepared by heating a mixture of 3-fluoro-5-(5-isopropyl-2-oxo-5-thien-2-yl-1,2,3,5-tetrahydro-4,1-benzoxazepin-7-yl)benzonitrile and Lawesson's reagent at reflux in toluene generally according to example 10. 1H-NMR (DMSO-d6) δ 12.09 (s, 1H), 8.1 (s, 1H), 7.96 (d, J=10.1 Hz, 1H), 7.88 (m, 2H), 7.83 (dd, J=8.5, 1.8 Hz, 1H), 7.48 (dd, J=4.9, 0.66 Hz, 1H), 7.40 (d, J=8.5 Hz, 1H), 7.03 (d, J=2.6 Hz, 1H), 7.00 (m, 1H), 4.48 (d, J=14.1 Hz, 1H), 4.37 (d, J=14.1 Hz, 1H), 2.96 (m, 1H), 0.93 (d, J=6.7 Hz, 3H), 0.87 (d, J=6.5 Hz, 3H); MS (ES) m/z 421 (M−H)−.

Provenance & Evidence