HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3,5-Difluorophenyl)boronic acid → 7-(3,5-Difluorophenyl)-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3,5-Difluorophenyl)boronic acid | HCID 2734338 | — |
| Reactant | 7-bromo-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one | HCID 68865814 | — |
| Product | 7-(3,5-Difluorophenyl)-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one | HCID 24956731 | — |
Reaction Steps
Prepared from 7-bromo-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one and 3,5-difluorobenzene boronic acid generally according to the coupling procedure described in example 1. 1H-NMR (DMSO-d6) δ 10.04 (s, 1H), 7.61-7.57 (m, 2H), 7.52-7.45 (m, 2H), 7.23-7.17 (m, 2H), 4.72 (s, 2H), 1.60 (s, 6H); MS (FI) m/z 304 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07598237B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-1c5064149d514cdd9a30b01ecab80394 |
| Source note | uspto-grants-2009_10 |