4-Fluorophenylboronic acid → HCID 24956011, compound

HRID 1816932Notes

Reaction equation

HRID 1816932 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][O:8][C:7]([CH3:14])([CH3:13])[C:6]=2[CH:15]=1.[F:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][CH:18]=1>>[CH3:13][C:7]1([CH3:14])[O:8][CH2:9][C:10](=[O:12])[NH:11][C:5]2[CH:4]=[CH:3][C:2]([C:20]3[CH:21]=[CH:22][C:17]([F:16])=[CH:18][CH:19]=3)=[CH:15][C:6]1=2

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 688658147-bromo-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one

Product 1

HCID 24956011HCID 24956011, compound

Procedure

Prepared from 7-bromo-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one and 4-fluoro benzeneboronic acid generally according to the coupling procedure described in example 1. 1H NMR (DMSO-d6): δ 9.92 (s, 1H), 7.64-7.67 (m, 2H), 7.41-7.46 (m, 2H), 7.17-7.25 (m, 2H), 7.12 (s, J=2.26 Hz, 1H), 4.21 (s, 2H), 1.57 (s, 6H); MS (ESI) m/z 286 ([M+H]+); MS (ESI) m/z 284 ([M−H]−).

Sources & evidence

ORD record
ord-d6412b87553a4e1ab99c9040022a9e9c
Source dataset
uspto-grants-2009_10
Patent number
US07598237B2

Reaction notes

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