3,5-Dichlorophenylboronic acid → HCID 24956014, compound

HRID 1816934Notes

Reaction equation

HRID 1816934 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][O:8][C:7]([CH3:14])([CH3:13])[C:6]=2[CH:15]=1.[Cl:16][C:17]1[CH:18]=[C:19](B(O)O)[CH:20]=[C:21]([Cl:23])[CH:22]=1>>[CH3:13][C:7]1([CH3:14])[O:8][CH2:9][C:10](=[O:12])[NH:11][C:5]2[CH:4]=[CH:3][C:2]([C:19]3[CH:18]=[C:17]([Cl:16])[CH:22]=[C:21]([Cl:23])[CH:20]=3)=[CH:15][C:6]1=2

Participants

3

Reactant 2

HCID 27343313,5-Dichlorophenylboronic acidHCID 688658147-bromo-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one

Product 1

HCID 24956014HCID 24956014, compound

Procedure

Prepared from 7-bromo-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one and 3,5-dichloro benzeneboronic acid generally according to the coupling procedure described in example 1. 1H NMR (DMSO-d6): δ 10.02 (s, 1H), 7.76 (s, 2H), 7.55-7.64 (m, 3H), 7.18 (d, J=8.45 Hz, 1H), 4.26 (s, 2H), 1.62 (s 6H); MS (ESI) m/z 336/338/340 ([M+H]+); MS (ESI) m/z 334/336/338 ([M−H]−).

Sources & evidence

ORD record
ord-36ea083defd64e238ff0c48444c0690f
Source dataset
uspto-grants-2009_10
Patent number
US07598237B2

Reaction notes

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