1-Bromo-3-chloro-5-fluorobenzene → HCID 24956376, compound

HRID 1816937Notes

Reaction equation

HRID 1816937 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][O:8][C:7]([CH3:14])([CH3:13])[C:6]=2[CH:15]=1.Br[C:17]1[CH:18]=[C:19]([F:24])[CH:20]=[C:21]([Cl:23])[CH:22]=1>>[CH3:13][C:7]1([CH3:14])[O:8][CH2:9][C:10](=[O:12])[NH:11][C:5]2[CH:4]=[CH:3][C:2]([C:17]3[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([F:24])[CH:18]=3)=[CH:15][C:6]1=2

Participants

3

Reactant 2

HCID 27362231-Bromo-3-chloro-5-fluorobenzeneHCID 688658147-bromo-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one

Product 1

HCID 24956376HCID 24956376, compound

Procedure

Prepared from 7-bromo-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one and 3-bromo-5-chloro-1-fluorobenzene generally according to the coupling procedure described in examples 82 and 1. 1H NMR (DMSO-d6): δ 10.01 (s, 1H), 7.61-7.65 (m, 4H), 7.36-7.39 (m, 1H), 7.18 (d, J=8.54 Hz, 1H), 4.26 (s, 2H), 1.62 (s, 6H); MS (ESI) m/z 320/322 ([M+H]+); MS (ESI) m/z 318/320 ([M−H]−). Anal. calcd for C17H15ClFNO2: C, 63.86; H, 4.73; N, 4.38. Found: C, 62.53; H, 4.55; N, 3.50.

Sources & evidence

ORD record
ord-55e5fc5cdbc3424381333670cd080291
Source dataset
uspto-grants-2009_10
Patent number
US07598237B2

Reaction notes

Loading…