Chloroacetyl chloride → HCID 68864171, compound

HRID 1816940Notes

Reaction equation

HRID 1816940 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:16]1[CH:20]=[CH:19][O:18][CH:17]=1)([C:11]1[CH:15]=[CH:14][O:13][CH:12]=1)[OH:10].[Cl:21][CH2:22][C:23](Cl)=[O:24]>>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:23](=[O:24])[CH2:22][Cl:21])=[C:3]([C:9]([C:11]2[CH:15]=[CH:14][O:13][CH:12]=2)([C:16]2[CH:20]=[CH:19][O:18][CH:17]=2)[OH:10])[CH:4]=1

Participants

3

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 68864279HCID 68864279, compound

Product 1

HCID 68864171HCID 68864171, compound

Procedure

Prepared from (2-amino-5-bromophenyl)[di(3-furyl)]methanol and chloroacetyl chloride generally according to procedure of described in example 1. 1H NMR (DMSO-d6): δ 10.69 (s, 1H), 8.14 (d, J=8.74 Hz, 1H), 7.69 (t, J=1.68 Hz, 2H), 7.54 (q, J=8.74 Hz, 1H), 7.51 (s, 1H), 7.32 (s, 2H), 7.02 (d, J=2.37 Hz, 1H), 6.43 (d, J=1.03 Hz, 2H), 4.26 (s, 2H); MS (ESI) m/z 408/410/412 ([M−H]−).

Sources & evidence

ORD record
ord-e8821d2ae8824c289b6f4bbc9aa4655b
Source dataset
uspto-grants-2009_10
Patent number
US07598237B2

Reaction notes

Loading…