HCID 68536788, compound → HCID 136330237, compound

Participants

Reaction Steps

(S)-1-[7-(4-benzyloxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]-3-[1-(3-methoxyphenyl)ethyl]urea (the compound obtained in Example 222; 7.83 g) was dissolved in acetic acid (600 ml). Thereafter, 10% palladium carbon (50% water content; 2.0 g) was added to the solution, and the obtained mixture was stirred at 40° C. overnight in a hydrogen atmosphere. The reaction solution was filtrated with a filter medium (Celite), and the resultant was then concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (eluted with 4% methanol-containing methylene chloride) to obtain the captioned compound (5.37 g).

Provenance & Evidence