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HRID1816972

反应详情

EQUATION

反应方程式

HRID 1816972 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)N1CC=C(B2OC(C)(C)C(C)(C)O2)CC1
HCID4642098

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate

C16H28BNO4

结构：COC(=O)c1cc(Br)ccc1F
HCID21525435

Methyl 5-bromo-2-fluorobenzoate

C8H6BrFO2

PRODUCTS

生成物

1
结构：COC(=O)c1cc(C2=CCN(C(=O)OC(C)(C)C)CC2)ccc1F
HCID57880514

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
催化剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

tert-Butyl 4-[4-fluoro-3-(methoxycarbonyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate was synthesized as described for INTERMEDIATE 32 using tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate (prepared according to Eastwood, P. R. Tetrahedron Lett., 41, 19, 2000, 3705-3708) and methyl 5-bromo-2-fluorobenzoate as starting material and PdCl2dppf.CH2Cl2 as a catalyst.