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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1817076Generated: October 25, 2026

4-Benzylpiperidine → 4-Benzyl-piperidine-1-carboxylic acid m-tolylamide

https://huagongshe.com/reaction/1817076

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-BenzylpiperidineHCID 31738—
Reactantm-Tolyl isocyanateHCID 69303—
Product4-Benzyl-piperidine-1-carboxylic acid m-tolylamideHCID 3833631—

Reaction Steps

The title compound was prepared from 4-benzylpiperidine and 3-methylphenyl isocyanate. 1H NMR (400 MHz, CDCl3): 7.32-7.07 (m, 8H), 6.84-6.80 (m, 1H), 6.41 (br s, 1H), 4.06-4.00 (m, 2H), 2.78 (td, J=13 Hz, 2.4 Hz, 2H), 2.55 (d, J=7.0 Hz, 2H), 2.30 (s, 3H), 1.77-1.64 (m, 3H), 1.28-1.16 (m, 2H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07598249B2
Source datasetuspto-grants-2009_10
ORD IDord-a0a8288463314e33acf4b8f53bd3a852
Source noteuspto-grants-2009_10