反应详情

1-Benzyl-4-benzyloxy-6-fluoro-1H-indole-2-carboxylic acid amide (570 mg, 1.52 mmol) in EtOH (20 ml) was added to a Parr vessel containing catalytic amount of 5% Pd on carbon. The vessel was purged with H2 at the pressure of 3.45 Bar. After shaking overnight, the reaction mixture was filtered through Celite and concentrated under reduced pressure. The residue was purified by flash chromatography to give 1-benzyl-6-fluoro-4-hydroxy-1H-indole-2-carboxylic acid amide as yellow solid (312 mg, 72%). MS: 285.2 (M+H)+.

1. customThe vessel was purged with H2 at the pressure of 3.45 Bar
2. filtrationthe reaction mixture was filtered through Celite
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified by flash chromatography