Phenyl isocyanate → 4-benzyl-N-phenylpiperazine-1-carboxamide

HRID 1817106Notes

Reaction equation

HRID 1817106 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:14]1([N:20]=[C:21]=[O:22])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[C:14]1([NH:20][C:21]([N:11]2[CH2:12][CH2:13][N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:9][CH2:10]2)=[O:22])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 7672Phenyl isocyanateHCID 759941-Benzylpiperazine

Product 1

HCID 7323074-benzyl-N-phenylpiperazine-1-carboxamide

Procedure

The title compound was prepared from 1-benzylpiperazine and phenyl isocyanate. 1H NMR (400 MHz, CDCl3): 7.35-7.22 (m, 9H), 7.02-6.97 (m, 1H), 6.55 (br s, 1H), 3.56 (s, 2H), 3.48-3.45 (m, 4H), 2.45-2.41 (m, 4H).

Sources & evidence

ORD record
ord-683435e6c92f4d3f823a39da996abba3
Source dataset
uspto-grants-2009_10
Patent number
US07598249B2

Reaction notes

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