反应详情

To a solution of 2,4,6trimethoxystyryl-3-amino-4-methoxybenzylsulfone (10 mmol) in toluene, chloroacetyl chloride (10 mmol) in dioxane (10 mL) was added and the solution was refluxed for 2 h. The solution was cooled and the solvent was removed in a rotary evaporator to give 2,4,6-trimethoxystyryl-3-chloroacetamido-4-methoxybenzylsulfone in 88% yield. M.p. 163-165° C. NMR (DMSO-d6) δ 3.83(s, 3H), 3.84(s, 6H), 3.85(s, 3H), 4.14(s, 2H), 4.22(s, 2H) 6.08 (s, 2H), 7.11-7.20(d, 1H vinylic), 6.90-8.33(m, aromatic), 8.89(s, 1H).

1. temperaturethe solution was refluxed for 2 h
2. temperatureThe solution was cooled
3. customthe solvent was removed in a rotary evaporator