2-Acetoxyisobutyroyl chloride → HCID 86598622, compound

HRID 1817141Notes

Reaction equation

HRID 1817141 reaction equation
[C:1]([O:4][C:5]([C:8](Cl)=[O:9])([CH3:7])[CH3:6])(=[O:3])[CH3:2].[CH3:11][O:12][C:13]1[CH:57]=[C:56]([O:58][CH3:59])[CH:55]=[C:54]([O:60][CH3:61])[C:14]=1/[CH:15]=[CH:16]/[CH:17]([S:27]([CH:30](/[CH:40]=[CH:41]/[C:42]1[C:47]([O:48][CH3:49])=[CH:46][C:45]([O:50][CH3:51])=[CH:44][C:43]=1[O:52][CH3:53])[C:31]1[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[C:33]([NH2:39])[CH:32]=1)(=[O:29])=[O:28])[C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([NH2:26])[CH:19]=1>>[CH3:61][O:60][C:54]1[CH:55]=[C:56]([O:58][CH3:59])[CH:57]=[C:13]([O:12][CH3:11])[C:14]=1/[CH:15]=[CH:16]/[CH:17]([S:27]([CH:30](/[CH:40]=[CH:41]/[C:42]1[C:43]([O:52][CH3:53])=[CH:44][C:45]([O:50][CH3:51])=[CH:46][C:47]=1[O:48][CH3:49])[C:31]1[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[C:33]([NH:39][C:8](=[O:9])[C:5]([O:4][C:1](=[O:3])[CH3:2])([CH3:7])[CH3:6])[CH:32]=1)(=[O:29])=[O:28])[C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([NH:26][C:8](=[O:9])[C:5]([CH3:7])([O:4][C:1](=[O:3])[CH3:2])[CH3:6])[CH:19]=1

Participants

3

Reactant 2

HCID 1234962-Acetoxyisobutyroyl chlorideHCID 67401517HCID 67401517, compound

Product 1

HCID 86598622HCID 86598622, compoundYield 98%

Procedure

A solution of 1-chlorocarbonyl-1-methylethyl acetate (10 mmol) and (E)-2,4,6-trimethoxystyryl-3-amino-4-methoxybenzylsulfone (10 mmol) was reacted according to General Method A. The crude product obtained was purified by column chromatography to yield the desired product in 98% yield. (m.p. 148-150° C.)

Workup

  1. customThe crude product obtained
  2. customwas purified by column chromatography

Sources & evidence

ORD record
ord-3e56390f217241d2a4f5a8ab076f5d8f
Source dataset
uspto-grants-2009_10
Patent number
US07598232B2

Reaction notes

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