反应详情

4-Methoxy-3-nitropyridine hydrochloride (11.2 g, 58.9 mmol) in ethanol (75 ml) was treated with a 70% solution of ethylamine in water (64 ml) and heated under reflux for 2 hours. After cooling to room temperature, the solvent was removed in vacuo and the residue dissolved in ethyl acetate and water. The mixture was extracted (×3) with ethyl acetate, washed with water and saturated aqueous sodium chloride solution before drying over magnesium sulfate. Evaporation of the solvent afforded the title compound (11.7 g, 96%).

1. temperatureheated
2. temperatureunder reflux for 2 hours
3. customthe solvent was removed in vacuo
4. dissolutionthe residue dissolved in ethyl acetate
5. extractionThe mixture was extracted (×3) with ethyl acetate
6. washwashed with water and saturated aqueous sodium chloride solution
7. dry with materialbefore drying over magnesium sulfate
8. customEvaporation of the solvent