反应详情

5-Bromo-3-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)pyrazin-2-amine (0.038 g, 0.12 mmol) (see Example 2), phenyl boronic acid (0.034 g, 0.27 mmol), dichlorobis(triphenylphosphine)palladium(II) (0.009 g, 0.012 mmol), potassium carbonate (0.045 g, 0.32 mmol), and an 8:1 mixture of acetonitrile:water (3 mL) were combined and subjected to 150° C. for 5 minutes in a SmithSynthesizer microwave. The resulting heterogeneous, black mixture was filtered through a celite pad, which was then washed with ethyl acetate and water. The mixture is extracted into ethyl acetate (×3) and washed with water and saturated sodium chloride. The combined organic layers are dried over magnesium sulfate, filtered and concentrated. The residue is purified on silica, eluting with 2.5% methanol in chloroform to afford the title compound (0.009 g, 23%).

1. filtrationThe resulting heterogeneous, black mixture was filtered through a celite pad, which
2. washwas then washed with ethyl acetate and water
3. extractionThe mixture is extracted into ethyl acetate (×3)
4. washwashed with water and saturated sodium chloride
5. dry with materialThe combined organic layers are dried over magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. customThe residue is purified on silica
9. washeluting with 2.5% methanol in chloroform