Potassium Carbonate → HCID 68862024, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	1-(tert-Butoxycarbonyl)indole-2-boronic Acid (contains varying amounts of Anhydride)	HCID 2773302	—
Reactant	5-bromo-3-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)pyrazin-2-amine	HCID 59852408	—
Catalyst	HCID 178418476	HCID 178418476	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 68862024	HCID 68862024	31.6%

Reaction Conditions

Temperature	200 °C

Reaction Steps

5-Bromo-3-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)pyrazin-2-amine (0.020 g, 0.063 mmol) (made in example 2), tert-butyl 2-borono-1H-indole-1-carboxylate (0.062 g, 0.25 mmol), Pd(PPh3)2Cl2 (0.004 g, 0.0056 mmol) and K2CO3 (0.050 g, 0.25 mmol) were combined in 0.5 mL of N,N-dimethylformamide and heated to 200° C. in the SmithSynthesizer microwave for 8 minutes. The reaction mixture was concentrated in vacuo and the residue purified by HPLC to give 0.008 g of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07598251B2
Source dataset	uspto-grants-2009_10
ORD ID	ord-44484034b15d46ad95c3fc3681b2ee98
Source note	uspto-grants-2009_10