p-Chlorothiophenol → HCID 67213328, compound

Participants

Reaction Steps

In ethanol (15 mL) were suspended ethyl 4-chloro-3-nitrobenzoate (1.10 g, 4.79 mmol), 4-chlorothiophenol (0.72 g, 4.98 mmol) and potassium carbonate (0.95 g, 6.78 mmol), and the suspension was heated under refluxing for 3 hours. The mixture was then placed under reduced pressure to distill the solvent off. After addition of water (100 mL), the mixture was subjected to extraction with ethyl acetate (100 mL×2) and dried over anhydrous sodium sulfate. The dry extract was placed under reduced pressure to distill the solvent off. The residue was purified-by silica gel column chromatography (ethyl acetate/hexane), to obtain 767 mg (yield 47%) of the titled compound as a yellow crystalline product.

Provenance & Evidence