HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1817177Generated: October 26, 2026
Veratrylamine → N-(3,4-dimethoxybenzyl)-7-(2-fluorobenzyl)4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine-2-amine
https://huagongshe.com/reaction/1817177
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Veratrylamine | HCID 79832 | — |
| Reactant | 2-chloro-7-(2-fluorobenzyl)-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine | HCID 21976427 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N-(3,4-dimethoxybenzyl)-7-(2-fluorobenzyl)4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine-2-amine | HCID 21976416 | 88.4% |
Reaction Steps
A solution of 2-chloro-7-(2-fluorobenzyl)-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine (254 mg, 0.78 mmol) in N-methylpyrrolidone (2 mL) was treated with veratrylamine (0.25 mL, 1.66 mmol), heated to 100° C. for 16 h and purified by chromatography (Heptane:EtOAc, 4:1) to give the title compound (316 mg, 88%) as a cream solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07598256B2 |
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| Source dataset | uspto-grants-2009_10 |
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| ORD ID | ord-1c36fde3337d4a65b799365dc4a52858 |
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| Source note | uspto-grants-2009_10 |
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