HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-Benzyl-6-fluoro-4-piperidin-4-yl-1H-indole-2-carboxylic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Trifluoroacetate | HCID 84468 | — |
| Reactant | 4-(1-Benzyl-2-carbamoyl-6-fluoro-1H-indol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester | HCID 68586044 | — |
| Product | 1-Benzyl-6-fluoro-4-piperidin-4-yl-1H-indole-2-carboxylic acid amide | HCID 24953072 | — |
Reaction Steps
1-Benzyl-6-fluoro-4-piperidin-4-yl-1H-indole-2-carboxylic acid amide was prepared as trifluoroacetate salt by hydrogenation of 4-(1-Benzyl-2-carbamoyl-6-fluoro-1H-indol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester, followed by deprotection with trifluoroacetic acid, using the procedure of steps 3 and 4 of Example 2. MS: (M+H)+ 352.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07741326B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-b950e1b62e0048149a0aa87dc89f4bd1 |
| Source note | uspto-grants-2010_06 |