Phenethyl bromide → HCID 11684527, compound

HRID 1817216Notes

Reaction equation

HRID 1817216 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:10]#[N:11])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:24][CH2:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[Br-:24].[C:10]([C:9]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[C:4]12[CH2:5][CH2:6][N+:1]([CH2:25][CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)([CH2:2][CH2:3]1)[CH2:8][CH2:7]2)#[N:11]

Participants

3

Reactant 2

HCID 7666Phenethyl bromideHCID 11716432HCID 11716432, compound

Product 1

HCID 11684527HCID 11684527, compoundYield 60.9%

Procedure

Following the general procedure outlined in Example 2, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)acetonitrile (0.0470 g, 0.155 mmol) and (2-bromoethyl)benzene (0.045 mL, 0.329 mmol) in 2CH3CN/3CHCl3 (4.0 mL) were reacted to give the desired product (0.0457 g, 60.9%). EI-MS m/z 407(M+) Rt (2.14 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-92cf7d11d0a14ec98e3220ce76ec798c
Source dataset
uspto-grants-2009_10
Patent number
US07598267B2

Reaction notes

Loading…