Methanol → Tert-butyl 4-hydroxypiperidine-1-carboxylate

HRID 181722Notes

Reaction equation

[BH4-:15].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11](=[O:14])[CH2:12][CH2:13]1.[CH3:17][OH:18].[Na+:16]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([OH:14])[CH2:12][CH2:13]1

Participants

Reactant 4

HCID 887Methanol

HCID 923Sodium ion

HCID 28123Borohydride

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record: ord-4d03eb953d7d4430b1374f6b3d07dba5
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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